Assay Detail
Binding
CHEMBL4832704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by TR-FRET based Adapta assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.33 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864109 | — | — | 1 | 8.40 |
| CHEMBL4857826 | — | — | 1 | 8.22 |
| CHEMBL4850655 | — | — | 1 | 8.05 |
| CHEMBL4857607 | — | — | 1 | 7.92 |
| CHEMBL4855904 | — | — | 1 | 7.89 |
| CHEMBL4863328 | — | — | 1 | 7.85 |
| CHEMBL4849042 | — | — | 1 | 7.85 |
| CHEMBL4866794 | — | — | 1 | 7.85 |
| CHEMBL4846278 | — | — | 1 | 7.62 |
| CHEMBL4859017 | — | — | 1 | 7.62 |
| CHEMBL4848126 | — | — | 1 | 7.60 |
| CHEMBL4867254 | — | — | 1 | 7.58 |
| CHEMBL4878811 | — | — | 1 | 7.55 |
| CHEMBL4878721 | — | — | 1 | 7.44 |
| CHEMBL4868011 | — | — | 1 | 7.44 |
| CHEMBL4861144 | — | — | 1 | 7.40 |
| CHEMBL4878615 | — | — | 1 | 7.40 |
| CHEMBL4873556 | — | — | 1 | 7.18 |
| CHEMBL4854845 | — | — | 1 | 7.06 |
| CHEMBL4857001 | — | — | 1 | 6.96 |
| CHEMBL4859466 | — | — | 1 | 6.77 |
| CHEMBL2071342 | — | — | 1 | 6.77 |
| CHEMBL4854857 | — | — | 1 | 6.48 |
| CHEMBL4855444 | — | — | 1 | 6.06 |
| CHEMBL4876331 | — | — | 1 | 5.96 |
| CHEMBL4866311 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864109 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4857826 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4850655 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4857607 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4855904 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4863328 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4849042 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4866794 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4846278 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4859017 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4848126 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4867254 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4878811 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4878721 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4868011 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4861144 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4878615 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4873556 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4854845 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4857001 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4859466 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2071342 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4854857 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4855444 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4876331 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4866311 | — | IC50 | = | 1800.0 | nM | 5.75 |