Assay Detail
Binding
CHEMBL4832751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PI3Kdelta expressed in rat fibroblast cells assessed as reduction in AKT phosphorylation at Ser473 residue incubated for 1 hr by AlphaScreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.70 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859017 | — | — | 1 | 6.17 |
| CHEMBL4857001 | — | — | 1 | 5.54 |
| CHEMBL2071342 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859017 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4857001 | — | IC50 | = | 2879.0 | nM | 5.54 |
| CHEMBL2071342 | — | IC50 | = | 4030.0 | nM | 5.39 |