Assay Detail
Functional
CHEMBL4832770
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Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.01 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868123 | — | — | 1 | 5.04 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.97 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868123 | — | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 10780.0 | nM | 4.97 |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | > | 50000.0 | nM | - |