Assay Detail
Binding
CHEMBL4833053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate by fluorometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of Quinazolines as Cruzain and <i>Tbr</i>CATL Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.19 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1458713 | — | — | 1 | 7.55 |
| CHEMBL4849695 | — | — | 1 | 5.62 |
| CHEMBL4855177 | — | — | 1 | 5.60 |
| CHEMBL4851626 | — | — | 1 | 5.16 |
| CHEMBL4865594 | — | — | 1 | 5.14 |
| CHEMBL597248 | — | — | 1 | 5.10 |
| CHEMBL4848906 | — | — | 1 | 4.87 |
| CHEMBL4849162 | — | — | 1 | 4.82 |
| CHEMBL4863654 | — | — | 1 | 4.80 |
| CHEMBL536813 | — | — | 1 | 4.75 |
| CHEMBL530354 | — | — | 1 | 4.75 |
| CHEMBL4878553 | — | — | 1 | 4.66 |
| CHEMBL4854591 | — | — | 1 | 4.60 |
| CHEMBL4853084 | — | — | 1 | - |
| CHEMBL4877020 | — | — | 1 | - |
| CHEMBL4856057 | — | — | 1 | - |
| CHEMBL4861314 | — | — | 1 | - |
| CHEMBL4851766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1458713 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4849695 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4855177 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4851626 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4865594 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL597248 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4848906 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4849162 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4863654 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL536813 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL530354 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4878553 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4854591 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4853084 | — | IC50 | - | — | - | |
| CHEMBL4877020 | — | IC50 | - | — | - | |
| CHEMBL4856057 | — | IC50 | - | — | - | |
| CHEMBL4861314 | — | IC50 | - | — | - | |
| CHEMBL4851766 | — | IC50 | - | — | - |