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Assay Detail

CHEMBL4833084

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Suppression of IL-17A production in human Th17 cells incubated for 4 days by IL-17 HTRF assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Th17
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
Narjes F, Llinas A, von Berg S, Jirholt J, Lever S, Pehrson R, Collins M, Malmberg A, Svanberg P, Xue Y, Olsson RI, Malmberg J, Hughes G, Hossain N, Grindebacke H, Leffler A, Krutrök N, Bäck E, Ramnegård M, Lepistö M, Thunberg L, Aagaard A, McPheat J, Hansson EL, Chen R, Xiong Y, Hansson TG.
J Med Chem (2021) 64 : 13807 -13829
PubMed 34464130 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 7.38 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4852138 1 8.22
CHEMBL4859385 1 8.15
CHEMBL4877500 1 8.15
CHEMBL4864990 1 8.15
CHEMBL4865776 1 8.00
CHEMBL4864604 1 7.96
CHEMBL4868864 1 7.96
CHEMBL4866908 1 7.96
CHEMBL4853971 1 7.92
CHEMBL4875842 1 7.85
CHEMBL4864731 1 7.82
CHEMBL4850055 1 7.77
CHEMBL4847308 1 7.70
CHEMBL4849302 1 7.70
CHEMBL4855387 1 7.66
CHEMBL4848388 1 7.64
CHEMBL4865352 1 7.58
CHEMBL4866227 1 7.55
CHEMBL4857284 1 7.54
CHEMBL4562895 1 7.52
CHEMBL4463668 1 7.52
CHEMBL4846059 1 7.51
CHEMBL4865573 1 7.51
CHEMBL4856430 1 7.48
CHEMBL4870856 1 7.41
CHEMBL4862137 1 7.33
CHEMBL4876902 1 7.27
CHEMBL4868619 1 7.24
CHEMBL4857395 1 7.24
CHEMBL4875667 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4852138 IC50 = 6.0 nM 8.22
CHEMBL4859385 IC50 = 7.0 nM 8.15
CHEMBL4864990 IC50 = 7.0 nM 8.15
CHEMBL4877500 IC50 = 7.0 nM 8.15
CHEMBL4865776 IC50 = 10.0 nM 8.00
CHEMBL4864604 IC50 = 11.0 nM 7.96
CHEMBL4868864 IC50 = 11.0 nM 7.96
CHEMBL4866908 IC50 = 11.0 nM 7.96
CHEMBL4853971 IC50 = 12.0 nM 7.92
CHEMBL4875842 IC50 = 14.0 nM 7.85
CHEMBL4864731 IC50 = 15.0 nM 7.82
CHEMBL4850055 IC50 = 17.0 nM 7.77
CHEMBL4847308 IC50 = 20.0 nM 7.70
CHEMBL4849302 IC50 = 20.0 nM 7.70
CHEMBL4855387 IC50 = 22.0 nM 7.66
CHEMBL4848388 IC50 = 23.0 nM 7.64
CHEMBL4865352 IC50 = 26.0 nM 7.58
CHEMBL4866227 IC50 = 28.0 nM 7.55
CHEMBL4857284 IC50 = 29.0 nM 7.54
CHEMBL4562895 IC50 = 30.0 nM 7.52
CHEMBL4463668 IC50 = 30.0 nM 7.52
CHEMBL4846059 IC50 = 31.0 nM 7.51
CHEMBL4865573 IC50 = 31.0 nM 7.51
CHEMBL4856430 IC50 = 33.0 nM 7.48
CHEMBL4870856 IC50 = 39.0 nM 7.41
CHEMBL4862137 IC50 = 47.0 nM 7.33
CHEMBL4876902 IC50 = 54.0 nM 7.27
CHEMBL4868619 IC50 = 57.0 nM 7.24
CHEMBL4857395 IC50 = 58.0 nM 7.24
CHEMBL4875667 IC50 = 60.0 nM 7.22
CHEMBL4847134 IC50 = 63.0 nM 7.20
CHEMBL4870339 IC50 = 72.0 nM 7.14
CHEMBL4850359 IC50 = 77.0 nM 7.11
CHEMBL4870686 IC50 = 86.0 nM 7.07
CHEMBL4868403 IC50 = 91.0 nM 7.04
CHEMBL4853746 IC50 = 102.0 nM 6.99
CHEMBL4856963 IC50 = 102.0 nM 6.99
CHEMBL4854122 IC50 = 115.0 nM 6.94
CHEMBL4872141 IC50 = 120.0 nM 6.92
CHEMBL4847761 IC50 = 127.0 nM 6.90
CHEMBL4878173 IC50 = 158.0 nM 6.80
CHEMBL4845714 IC50 = 224.0 nM 6.65
CHEMBL4855766 IC50 = 248.0 nM 6.61
CHEMBL4868767 IC50 = 286.0 nM 6.54
CHEMBL4869175 IC50 = 287.0 nM 6.54
CHEMBL4852181 IC50 = 360.0 nM 6.44
CHEMBL4875795 IC50 = 423.0 nM 6.37
CHEMBL4856950 IC50 > 3330.0 nM -