Assay Detail
Binding
CHEMBL4833336
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Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 5.26 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867183 | — | — | 1 | 6.10 |
| CHEMBL4875121 | — | — | 1 | 6.10 |
| CHEMBL4858278 | — | — | 1 | 5.72 |
| CHEMBL4860199 | — | — | 1 | 5.24 |
| CHEMBL4858896 | — | — | 1 | 5.07 |
| CHEMBL4850898 | — | — | 1 | 5.00 |
| CHEMBL4853693 | — | — | 1 | 4.85 |
| CHEMBL4853073 | — | — | 1 | 4.66 |
| CHEMBL4864623 | — | — | 1 | 4.58 |
| CHEMBL4857636 | — | — | 1 | - |
| CHEMBL4859744 | — | — | 1 | - |
| CHEMBL4851154 | — | — | 1 | - |
| CHEMBL4858354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867183 | — | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL4875121 | — | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL4858278 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL4860199 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL4858896 | — | Kd | = | 8600.0 | nM | 5.07 |
| CHEMBL4850898 | — | Kd | = | 9900.0 | nM | 5.00 |
| CHEMBL4853693 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL4853073 | — | Kd | = | 22000.0 | nM | 4.66 |
| CHEMBL4864623 | — | Kd | = | 26200.0 | nM | 4.58 |
| CHEMBL4857636 | — | Kd | - | — | - | |
| CHEMBL4859744 | — | Kd | > | 80000.0 | nM | - |
| CHEMBL4851154 | — | Kd | - | — | - | |
| CHEMBL4858354 | — | Kd | = | 160000.0 | nM | - |