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Assay Detail

CHEMBL4833337

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Binding
Binding affinity to 6His-tagged HMGB1 BoxA (unknown origin) incubated for 15 mins by MST analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

High mobility group protein B1 (CHEMBL2311236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction.
Sgrignani J, Cecchinato V, Fassi EMA, D'Agostino G, Garofalo M, Danelon G, Pedotti M, Simonelli L, Varani L, Grazioso G, Uguccioni M, Cavalli A.
J Med Chem (2021) 64 : 13439 -13450
PubMed 34510899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.10 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4867183 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4867183 Kd = 800.0 nM 6.10