Assay Detail
Functional
CHEMBL4833341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.01 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 7.09 |
| CHEMBL4854072 | — | — | 1 | 6.32 |
| CHEMBL132623 | ASCOCHLORIN | — | 1 | 5.96 |
| CHEMBL4854950 | — | — | 1 | 5.77 |
| CHEMBL4854893 | — | — | 1 | 5.22 |
| CHEMBL133046 | ASCOFURANONE | — | 1 | 5.15 |
| CHEMBL4847651 | — | — | 1 | 5.12 |
| CHEMBL4865354 | — | — | 1 | 4.96 |
| CHEMBL560024 | ILICICOLIN C | — | 1 | 4.89 |
| CHEMBL4854654 | — | — | 1 | 4.82 |
| CHEMBL4857846 | — | — | 1 | 4.80 |
| CHEMBL4846020 | — | — | 1 | 4.70 |
| CHEMBL4875611 | — | — | 1 | 4.58 |
| CHEMBL550973 | ILICICOLIN F | — | 1 | 4.57 |
| CHEMBL4845837 | — | — | 1 | 4.54 |
| CHEMBL4850971 | — | — | 1 | 4.47 |
| CHEMBL4851177 | — | — | 1 | 4.42 |
| CHEMBL4852487 | — | — | 1 | 4.35 |
| CHEMBL4859267 | — | — | 1 | 4.31 |
| CHEMBL4845865 | — | — | 1 | 4.24 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | - |
| CHEMBL4877116 | — | — | 1 | - |
| CHEMBL4861975 | — | — | 1 | - |
| CHEMBL4870556 | — | — | 1 | - |
| CHEMBL4874137 | — | — | 1 | - |
| CHEMBL4846724 | — | — | 1 | - |
| CHEMBL4866258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4854072 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL132623 | ASCOCHLORIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4854950 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4854893 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL133046 | ASCOFURANONE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4847651 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4865354 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL560024 | ILICICOLIN C | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4854654 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4857846 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4846020 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4875611 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL550973 | ILICICOLIN F | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4845837 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4850971 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4851177 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4852487 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4859267 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4845865 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL185 | FLUOROURACIL | IC50 | > | 20000.0 | nM | - |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | > | 20000.0 | nM | - |
| CHEMBL4877116 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL4861975 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL4870556 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL4874137 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL4846724 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL4866258 | — | IC50 | > | 60000.0 | nM | - |