Assay Detail
Binding
CHEMBL4833342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal His-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli using DL-dihydroorotic acid as substrate and Q0 as coenzyme by DCIP based assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.39 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 8.30 |
| CHEMBL4854072 | — | — | 1 | 7.13 |
| CHEMBL4854950 | — | — | 1 | 6.41 |
| CHEMBL4865354 | — | — | 1 | 6.14 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 5.96 |
| CHEMBL132623 | ASCOCHLORIN | — | 1 | 5.89 |
| CHEMBL4857846 | — | — | 1 | 5.80 |
| CHEMBL560024 | ILICICOLIN C | — | 1 | 5.72 |
| CHEMBL4846020 | — | — | 1 | 5.43 |
| CHEMBL4850971 | — | — | 1 | 5.41 |
| CHEMBL4854654 | — | — | 1 | 5.33 |
| CHEMBL4845837 | — | — | 1 | 5.30 |
| CHEMBL133046 | ASCOFURANONE | — | 1 | 5.27 |
| CHEMBL4852487 | — | — | 1 | 5.19 |
| CHEMBL4845865 | — | — | 1 | 5.10 |
| CHEMBL4874137 | — | — | 1 | 5.03 |
| CHEMBL550973 | ILICICOLIN F | — | 1 | 4.96 |
| CHEMBL4861975 | — | — | 1 | 4.96 |
| CHEMBL4846724 | — | — | 1 | 4.89 |
| CHEMBL4877116 | — | — | 1 | 4.82 |
| CHEMBL4859267 | — | — | 1 | 4.70 |
| CHEMBL4854893 | — | — | 1 | 4.52 |
| CHEMBL4866258 | — | — | 1 | 4.51 |
| CHEMBL4847651 | — | — | 1 | 4.50 |
| CHEMBL4870556 | — | — | 1 | 4.47 |
| CHEMBL4851177 | — | — | 1 | 4.38 |
| CHEMBL4875611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4854072 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4854950 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4865354 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL132623 | ASCOCHLORIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4857846 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL560024 | ILICICOLIN C | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4846020 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4850971 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4854654 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4845837 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL133046 | ASCOFURANONE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4852487 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4845865 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4874137 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL550973 | ILICICOLIN F | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4861975 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4846724 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4877116 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4859267 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4854893 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4866258 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4847651 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4870556 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4851177 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4875611 | — | IC50 | > | 60000.0 | nM | - |