Assay Detail
Functional
CHEMBL4833430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 JPN/TY/WK-251 infected in Vero E6 cells after 72 hrs by RT-qPCR analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.80 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.92 |
| CHEMBL490820 | — | — | 1 | 5.55 |
| CHEMBL4853474 | — | — | 1 | 5.51 |
| CHEMBL4853263 | — | — | 1 | 5.09 |
| CHEMBL4858401 | — | — | 1 | 4.94 |
| CHEMBL4846171 | — | — | 1 | 4.85 |
| CHEMBL4874639 | — | — | 1 | 4.82 |
| CHEMBL4852507 | — | — | 1 | 4.82 |
| CHEMBL4862535 | — | — | 1 | 4.71 |
| CHEMBL4872700 | — | — | 1 | 4.52 |
| CHEMBL510559 | — | — | 1 | 4.36 |
| CHEMBL4879042 | — | — | 1 | 4.25 |
| CHEMBL4848976 | — | — | 1 | 4.24 |
| CHEMBL4857985 | — | — | 1 | 4.24 |
| CHEMBL496316 | — | — | 1 | 4.16 |
| CHEMBL4864512 | — | — | 1 | - |
| CHEMBL4866309 | — | — | 1 | - |
| CHEMBL4875182 | — | — | 1 | - |
| CHEMBL4860159 | — | — | 1 | - |
| CHEMBL4864365 | — | — | 1 | - |
| CHEMBL4874041 | — | — | 1 | - |
| CHEMBL4859897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL490820 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4853474 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4853263 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4858401 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4846171 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4874639 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4852507 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4862535 | — | EC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4872700 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL510559 | — | EC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4879042 | — | EC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL4848976 | — | EC50 | = | 57100.0 | nM | 4.24 |
| CHEMBL4857985 | — | EC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL496316 | — | EC50 | = | 69800.0 | nM | 4.16 |
| CHEMBL4864512 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4866309 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4875182 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4860159 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4864365 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4874041 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4859897 | — | EC50 | > | 100000.0 | nM | - |