Assay Detail
Binding
CHEMBL4833458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli incubated for 60 mins by tryptophan intrinsic fluorescence method
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.47 | 6.01 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | 4.0 | 2 | 6.01 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.96 |
| CHEMBL5416410 | DASATINIB | 4.0 | 2 | 5.51 |
| CHEMBL4847991 | — | — | 2 | 5.19 |
| CHEMBL1096 | AMLEXANOX | 4.0 | 2 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | Kd | = | 980.0 | nM | 6.01 |
| CHEMBL290106 | BITHIONOL | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL5416410 | DASATINIB | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL4847991 | — | Kd | = | 6500.0 | nM | 5.19 |
| CHEMBL1096 | AMLEXANOX | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL1324 | TOLCAPONE | Activity | - | — | - | |
| CHEMBL4847991 | — | Activity | - | — | - | |
| CHEMBL1096 | AMLEXANOX | Activity | - | — | - | |
| CHEMBL5416410 | DASATINIB | Activity | - | — | - | |
| CHEMBL290106 | BITHIONOL | Activity | - | — | - |