Assay Detail
Binding
CHEMBL4833461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stabilization of TTR V30M mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance method
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.52 | 5.62 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.62 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 2 | 5.58 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 2 | 5.50 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 2 | 5.46 |
| CHEMBL1086440 | TRICLABENDAZOLE | 4.0 | 2 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290106 | BITHIONOL | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2103837 | TAFAMIDIS | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1324 | TOLCAPONE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL898 | DIFLUNISAL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1086440 | TRICLABENDAZOLE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2103837 | TAFAMIDIS | Activity | - | — | - | |
| CHEMBL898 | DIFLUNISAL | Activity | - | — | - | |
| CHEMBL1324 | TOLCAPONE | Activity | - | — | - | |
| CHEMBL290106 | BITHIONOL | Activity | - | — | - | |
| CHEMBL1086440 | TRICLABENDAZOLE | Activity | - | — | - |