Assay Detail
Binding
CHEMBL4833467
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Binding affinity to TTR V30M mutant (unknown origin) by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.71 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290106 | BITHIONOL | 4.0 | 1 | 7.21 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 7.02 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.70 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290106 | BITHIONOL | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL1324 | TOLCAPONE | Kd | = | 95.0 | nM | 7.02 |
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 1300.0 | nM | 5.89 |