Assay Detail
Functional
CHEMBL4833586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.80 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864193 | — | — | 1 | 5.96 |
| CHEMBL4867326 | — | — | 1 | 5.39 |
| CHEMBL4857894 | — | — | 1 | 5.37 |
| CHEMBL4878528 | — | — | 1 | 5.32 |
| CHEMBL4856517 | — | — | 1 | 5.23 |
| CHEMBL4853340 | — | — | 1 | 4.83 |
| CHEMBL498485 | ICARITIN | 3.0 | 1 | 4.68 |
| CHEMBL4847364 | — | — | 1 | 4.56 |
| CHEMBL4877755 | — | — | 1 | 4.53 |
| CHEMBL4874187 | — | — | 1 | 4.37 |
| CHEMBL4879180 | — | — | 1 | 4.35 |
| CHEMBL4861295 | — | — | 1 | 4.25 |
| CHEMBL4879369 | — | — | 1 | 4.22 |
| CHEMBL4855737 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864193 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4867326 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4857894 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4878528 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4856517 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4853340 | — | IC50 | = | 14910.0 | nM | 4.83 |
| CHEMBL498485 | ICARITIN | IC50 | = | 20780.0 | nM | 4.68 |
| CHEMBL4847364 | — | IC50 | = | 27560.0 | nM | 4.56 |
| CHEMBL4877755 | — | IC50 | = | 29830.0 | nM | 4.53 |
| CHEMBL4874187 | — | IC50 | = | 42790.0 | nM | 4.37 |
| CHEMBL4879180 | — | IC50 | = | 44790.0 | nM | 4.35 |
| CHEMBL4861295 | — | IC50 | = | 56650.0 | nM | 4.25 |
| CHEMBL4879369 | — | IC50 | = | 60420.0 | nM | 4.22 |
| CHEMBL4855737 | — | IC50 | = | 66230.0 | nM | 4.18 |