Assay Detail
Binding
CHEMBL4834033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heterocyclic Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.44 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854356 | — | — | 1 | 9.70 |
| CHEMBL4852401 | — | — | 1 | 9.52 |
| CHEMBL4851260 | — | — | 1 | 9.42 |
| CHEMBL4859161 | — | — | 1 | 9.40 |
| CHEMBL4855859 | — | — | 1 | 9.39 |
| CHEMBL4857243 | — | — | 1 | 9.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854356 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4852401 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4851260 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL4859161 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4855859 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4857243 | — | IC50 | = | 0.59 | nM | 9.23 |