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Assay Detail

CHEMBL4834053

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Binding
Binding affinity to human serum albumin by fluorescence polarization assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Albumin (CHEMBL3253)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.
Gironda-Martínez A, Gorre ÉMD, Prati L, Gosalbes JF, Dakhel S, Cazzamalli S, Samain F, Donckele EJ, Neri D.
J Med Chem (2021) 64 : 17496 -17510
PubMed 34821503 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 22 6.26 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4874500 1 7.70
CHEMBL4875916 1 7.52
CHEMBL4852232 1 7.16
CHEMBL4845813 1 6.77
CHEMBL4870031 1 6.68
CHEMBL4866037 1 6.66
CHEMBL4866759 1 6.57
CHEMBL4877313 1 6.54
CHEMBL4856339 1 6.51
CHEMBL4869829 1 6.41
CHEMBL4879282 1 6.37
CHEMBL4873867 1 6.24
CHEMBL4855828 1 6.11
CHEMBL4870525 1 6.09
CHEMBL4863588 1 6.00
CHEMBL4876740 1 5.82
CHEMBL4872601 1 5.77
CHEMBL4851618 1 5.70
CHEMBL4861027 1 5.48
CHEMBL4867370 1 5.40
CHEMBL4871406 1 5.14
CHEMBL4846246 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4874500 Kd = 20.0 nM 7.70
CHEMBL4875916 Kd = 30.0 nM 7.52
CHEMBL4852232 Kd = 70.0 nM 7.16
CHEMBL4845813 Kd = 170.0 nM 6.77
CHEMBL4870031 Kd = 210.0 nM 6.68
CHEMBL4866037 Kd = 220.0 nM 6.66
CHEMBL4866759 Kd = 270.0 nM 6.57
CHEMBL4877313 Kd = 290.0 nM 6.54
CHEMBL4856339 Kd = 310.0 nM 6.51
CHEMBL4869829 Kd = 390.0 nM 6.41
CHEMBL4879282 Kd = 430.0 nM 6.37
CHEMBL4873867 Kd = 580.0 nM 6.24
CHEMBL4855828 Kd = 780.0 nM 6.11
CHEMBL4870525 Kd = 820.0 nM 6.09
CHEMBL4863588 Kd = 1000.0 nM 6.00
CHEMBL4876740 Kd = 1500.0 nM 5.82
CHEMBL4872601 Kd = 1700.0 nM 5.77
CHEMBL4851618 Kd = 2000.0 nM 5.70
CHEMBL4861027 Kd = 3300.0 nM 5.48
CHEMBL4867370 Kd = 4000.0 nM 5.40
CHEMBL4871406 Kd = 7200.0 nM 5.14
CHEMBL4846246 Kd = 9600.0 nM 5.02