Assay Detail
Functional
CHEMBL4834207
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.23 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847367 | — | — | 1 | 6.04 |
| CHEMBL4868139 | — | — | 1 | 5.87 |
| CHEMBL4860351 | — | — | 1 | 5.80 |
| CHEMBL4875150 | — | — | 1 | 5.78 |
| CHEMBL4859874 | — | — | 1 | 5.76 |
| CHEMBL4851817 | — | — | 1 | 5.66 |
| CHEMBL4878869 | — | — | 1 | 5.64 |
| CHEMBL4878702 | — | — | 1 | 5.61 |
| CHEMBL4871872 | — | — | 1 | 5.61 |
| CHEMBL4876212 | — | — | 1 | 5.58 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.56 |
| CHEMBL4865658 | — | — | 1 | 5.56 |
| CHEMBL4866848 | — | — | 1 | 5.56 |
| CHEMBL4864896 | — | — | 1 | 5.53 |
| CHEMBL4859358 | — | — | 1 | 5.53 |
| CHEMBL4878062 | — | — | 1 | 5.50 |
| CHEMBL4852643 | — | — | 1 | 5.46 |
| CHEMBL4876534 | — | — | 1 | 5.34 |
| CHEMBL4858919 | — | — | 1 | 5.29 |
| CHEMBL4846899 | — | — | 1 | 5.24 |
| CHEMBL4853057 | — | — | 1 | 5.17 |
| CHEMBL563939 | — | — | 1 | 5.13 |
| CHEMBL4877106 | — | — | 1 | 5.09 |
| CHEMBL4868646 | — | — | 1 | 5.06 |
| CHEMBL4865411 | — | — | 1 | 5.04 |
| CHEMBL4865799 | — | — | 1 | 5.01 |
| CHEMBL4298697 | — | — | 1 | 4.99 |
| CHEMBL4853452 | — | — | 1 | 4.87 |
| CHEMBL4852105 | — | — | 1 | 4.85 |
| CHEMBL4868544 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847367 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4868139 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4860351 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4875150 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4859874 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4851817 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4878869 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4878702 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4871872 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4876212 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4865658 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL4866848 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4864896 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4859358 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4878062 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4852643 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4876534 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL4858919 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL4846899 | — | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL4853057 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL563939 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL4877106 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL4868646 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL4865411 | — | IC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL4865799 | — | IC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL4298697 | — | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL4853452 | — | IC50 | = | 13520.0 | nM | 4.87 |
| CHEMBL4852105 | — | IC50 | = | 14180.0 | nM | 4.85 |
| CHEMBL4868544 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL4862216 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4872364 | — | IC50 | = | 17360.0 | nM | 4.76 |
| CHEMBL4865054 | — | IC50 | = | 27310.0 | nM | 4.56 |
| CHEMBL4845968 | — | IC50 | = | 28620.0 | nM | 4.54 |
| CHEMBL4863676 | — | IC50 | = | 33540.0 | nM | 4.47 |
| CHEMBL4869475 | — | IC50 | = | 40220.0 | nM | 4.40 |
| CHEMBL4861890 | — | IC50 | = | 60100.0 | nM | 4.22 |
| CHEMBL1085588 | — | IC50 | > | 100000.0 | nM | - |