Assay Detail
Functional
CHEMBL4834208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.25 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859358 | — | — | 1 | 5.89 |
| CHEMBL4868139 | — | — | 1 | 5.78 |
| CHEMBL4875150 | — | — | 1 | 5.75 |
| CHEMBL4866848 | — | — | 1 | 5.66 |
| CHEMBL4864896 | — | — | 1 | 5.65 |
| CHEMBL4860351 | — | — | 1 | 5.63 |
| CHEMBL4859874 | — | — | 1 | 5.61 |
| CHEMBL4847367 | — | — | 1 | 5.60 |
| CHEMBL4878702 | — | — | 1 | 5.59 |
| CHEMBL4871872 | — | — | 1 | 5.59 |
| CHEMBL4862216 | — | — | 1 | 5.56 |
| CHEMBL4865411 | — | — | 1 | 5.52 |
| CHEMBL4878062 | — | — | 1 | 5.51 |
| CHEMBL4851817 | — | — | 1 | 5.50 |
| CHEMBL4852643 | — | — | 1 | 5.45 |
| CHEMBL4876212 | — | — | 1 | 5.45 |
| CHEMBL4878869 | — | — | 1 | 5.40 |
| CHEMBL4853452 | — | — | 1 | 5.22 |
| CHEMBL4853057 | — | — | 1 | 5.19 |
| CHEMBL4865658 | — | — | 1 | 5.18 |
| CHEMBL4877106 | — | — | 1 | 5.16 |
| CHEMBL4298697 | — | — | 1 | 5.16 |
| CHEMBL4858919 | — | — | 1 | 5.12 |
| CHEMBL4868646 | — | — | 1 | 5.11 |
| CHEMBL4876534 | — | — | 1 | 5.11 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.07 |
| CHEMBL4846899 | — | — | 1 | 5.07 |
| CHEMBL563939 | — | — | 1 | 4.97 |
| CHEMBL4865799 | — | — | 1 | 4.97 |
| CHEMBL4865054 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859358 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4868139 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4875150 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4866848 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4864896 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4860351 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4859874 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4847367 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4878702 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL4871872 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL4862216 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4865411 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4878062 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4851817 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4876212 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4852643 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4878869 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL4853452 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL4853057 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL4865658 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL4298697 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4877106 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL4858919 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL4868646 | — | IC50 | = | 7760.0 | nM | 5.11 |
| CHEMBL4876534 | — | IC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL4846899 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL563939 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4865799 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4865054 | — | IC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL4868544 | — | IC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL4845968 | — | IC50 | = | 12990.0 | nM | 4.89 |
| CHEMBL4872364 | — | IC50 | = | 13860.0 | nM | 4.86 |
| CHEMBL4852105 | — | IC50 | = | 21650.0 | nM | 4.67 |
| CHEMBL4861890 | — | IC50 | = | 23530.0 | nM | 4.63 |
| CHEMBL4863676 | — | IC50 | = | 24640.0 | nM | 4.61 |
| CHEMBL4869475 | — | IC50 | = | 72050.0 | nM | 4.14 |
| CHEMBL1085588 | — | IC50 | > | 100000.0 | nM | - |