Assay Detail
Functional
CHEMBL4834209
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.99 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.64 |
| CHEMBL4875150 | — | — | 1 | 5.41 |
| CHEMBL4866848 | — | — | 1 | 5.39 |
| CHEMBL4847367 | — | — | 1 | 5.35 |
| CHEMBL4860351 | — | — | 1 | 5.34 |
| CHEMBL4859874 | — | — | 1 | 5.32 |
| CHEMBL4865799 | — | — | 1 | 5.30 |
| CHEMBL4865658 | — | — | 1 | 5.23 |
| CHEMBL4878062 | — | — | 1 | 5.18 |
| CHEMBL4851817 | — | — | 1 | 5.17 |
| CHEMBL4853057 | — | — | 1 | 5.15 |
| CHEMBL4853452 | — | — | 1 | 5.14 |
| CHEMBL4868139 | — | — | 1 | 5.11 |
| CHEMBL4868544 | — | — | 1 | 5.11 |
| CHEMBL4852643 | — | — | 1 | 5.09 |
| CHEMBL4846899 | — | — | 1 | 5.07 |
| CHEMBL4876212 | — | — | 1 | 5.06 |
| CHEMBL4864896 | — | — | 1 | 5.05 |
| CHEMBL4871872 | — | — | 1 | 5.02 |
| CHEMBL4878702 | — | — | 1 | 5.02 |
| CHEMBL4876534 | — | — | 1 | 5.02 |
| CHEMBL4859358 | — | — | 1 | 5.01 |
| CHEMBL4858919 | — | — | 1 | 4.97 |
| CHEMBL4872364 | — | — | 1 | 4.93 |
| CHEMBL563939 | — | — | 1 | 4.92 |
| CHEMBL4878869 | — | — | 1 | 4.90 |
| CHEMBL4852105 | — | — | 1 | 4.86 |
| CHEMBL4865411 | — | — | 1 | 4.86 |
| CHEMBL4877106 | — | — | 1 | 4.85 |
| CHEMBL4868646 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4875150 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4866848 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4847367 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4860351 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL4859874 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL4865799 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4865658 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4878062 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4851817 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4853057 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4853452 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4868139 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL4868544 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL4852643 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL4846899 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL4876212 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL4864896 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL4876534 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL4878702 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL4871872 | — | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL4859358 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL4858919 | — | IC50 | = | 10590.0 | nM | 4.97 |
| CHEMBL4872364 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL563939 | — | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL4878869 | — | IC50 | = | 12490.0 | nM | 4.90 |
| CHEMBL4852105 | — | IC50 | = | 13970.0 | nM | 4.86 |
| CHEMBL4865411 | — | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL4877106 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL4868646 | — | IC50 | = | 17880.0 | nM | 4.75 |
| CHEMBL4845968 | — | IC50 | = | 23480.0 | nM | 4.63 |
| CHEMBL4862216 | — | IC50 | = | 23640.0 | nM | 4.63 |
| CHEMBL4298697 | — | IC50 | = | 26130.0 | nM | 4.58 |
| CHEMBL4865054 | — | IC50 | = | 59650.0 | nM | 4.22 |
| CHEMBL4861890 | — | IC50 | = | 69490.0 | nM | 4.16 |
| CHEMBL4863676 | — | IC50 | = | 86650.0 | nM | 4.06 |
| CHEMBL4869475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1085588 | — | IC50 | > | 100000.0 | nM | - |