Assay Detail
Binding
CHEMBL4834262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858720 | — | — | 1 | 7.37 |
| CHEMBL169390 | — | — | 1 | 7.24 |
| CHEMBL4854822 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858720 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL169390 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4854822 | — | IC50 | = | 4200.0 | nM | 5.38 |