Assay Detail
Binding
CHEMBL4834316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 days by d CellTiter Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LC-2-ad |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET (CHEMBL3430904) ↗| Type | CHIMERIC PROTEIN |
| Organism | Homo sapiens |
Publication
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.26 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4874648 | — | — | 1 | 7.46 |
| CHEMBL4877264 | — | — | 1 | 7.34 |
| CHEMBL4859681 | — | — | 1 | 7.29 |
| CHEMBL4857808 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4874648 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4877264 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4859681 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4857808 | — | IC50 | = | 110.0 | nM | 6.96 |