Assay Detail
Binding
CHEMBL4834558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IDO1 expressed in HEK293T cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 7 hrs by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871312 | — | — | 1 | 7.47 |
| CHEMBL2148074 | — | — | 1 | 6.96 |
| CHEMBL2147989 | — | — | 1 | 6.21 |
| CHEMBL4455007 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871312 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2148074 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2147989 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4455007 | — | IC50 | = | 880.0 | nM | 6.06 |