Assay Detail
Binding
CHEMBL4834989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant UAE (unknown origin) in presence of ATP at Km concentration by HTRF assay
63
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 6.52 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4878088 | — | — | 1 | 7.24 |
| CHEMBL4852015 | — | — | 1 | 6.33 |
| CHEMBL4860471 | — | — | 1 | 6.31 |
| CHEMBL4878832 | — | — | 1 | 6.21 |
| CHEMBL4849766 | — | — | 1 | - |
| CHEMBL4856040 | — | — | 1 | - |
| CHEMBL4862248 | — | — | 2 | - |
| CHEMBL4861509 | — | — | 1 | - |
| CHEMBL4862587 | — | — | 1 | - |
| CHEMBL4848140 | — | — | 1 | - |
| CHEMBL4873487 | — | — | 1 | - |
| CHEMBL4858933 | — | — | 1 | - |
| CHEMBL4867650 | — | — | 1 | - |
| CHEMBL4862901 | — | — | 1 | - |
| CHEMBL4858495 | — | — | 1 | - |
| CHEMBL4873956 | — | — | 1 | - |
| CHEMBL4865157 | — | — | 1 | - |
| CHEMBL4869956 | — | — | 1 | - |
| CHEMBL4860960 | — | — | 1 | - |
| CHEMBL4872222 | — | — | 1 | - |
| CHEMBL4876899 | — | — | 1 | - |
| CHEMBL4848114 | — | — | 1 | - |
| CHEMBL4852516 | — | — | 1 | - |
| CHEMBL4854038 | — | — | 1 | - |
| CHEMBL4877684 | — | — | 1 | - |
| CHEMBL4864361 | — | — | 1 | - |
| CHEMBL4850183 | — | — | 1 | - |
| CHEMBL4860917 | — | — | 1 | - |
| CHEMBL4856793 | — | — | 2 | - |
| CHEMBL4848442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4878088 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4852015 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL4860471 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL4878832 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL4858495 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4862322 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4873956 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4865157 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4856040 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4861656 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4851718 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4869144 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4865086 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4849931 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4869112 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4853650 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4865609 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4855027 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4866833 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4864280 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4869340 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4859486 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4870385 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4866755 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4865787 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4861240 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4869021 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4872222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4852516 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4856793 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4856793 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4860917 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4850183 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4864361 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4877684 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4854038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4848114 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4848442 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4876899 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4862901 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4860960 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4869956 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4849766 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4862248 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4861509 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4862587 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4848140 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4873487 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4858933 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4867650 | — | IC50 | > | 1000.0 | nM | - |