Assay Detail
Functional
CHEMBL4835544
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Inhibition of SAM production in human HCT-116 cells isogenic cell model measured after 72 hrs by LC-MS/MS analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous <i>MTAP</i> Deletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.00 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559088 | — | — | 1 | 8.10 |
| CHEMBL4584451 | — | — | 1 | 7.82 |
| CHEMBL4529030 | — | — | 1 | 7.80 |
| CHEMBL4521249 | — | — | 1 | 7.75 |
| CHEMBL4558617 | — | — | 1 | 7.68 |
| CHEMBL4568226 | — | — | 1 | 7.60 |
| CHEMBL4585665 | — | — | 1 | 7.19 |
| CHEMBL4560666 | — | — | 1 | 7.00 |
| CHEMBL4865263 | — | — | 1 | 6.97 |
| CHEMBL4878283 | — | — | 1 | 6.23 |
| CHEMBL4874436 | — | — | 1 | 5.12 |
| CHEMBL4573938 | — | — | 1 | 4.70 |
| CHEMBL4582312 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559088 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4584451 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4529030 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4521249 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4558617 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4568226 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4585665 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4560666 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4865263 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4878283 | — | IC50 | = | 588.0 | nM | 6.23 |
| CHEMBL4874436 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL4573938 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4582312 | — | IC50 | - | — | - |