Assay Detail
Functional
CHEMBL4835672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against asexual stage (I/III) Plasmodium falciparum NF54 early gametocytes transfected with GFP-Luc assessed as inhibition of exflagellation of male gametes incubated for 48 hrs by microscopy based luciferase reporter gene assay relative to control
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and <i>In Vivo</i> Oral Efficacy Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.19 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853530 | — | — | 1 | 7.25 |
| CHEMBL4846075 | — | — | 1 | 7.01 |
| CHEMBL4851068 | — | — | 1 | 6.96 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.72 |
| CHEMBL4853001 | — | — | 1 | 6.68 |
| CHEMBL4879051 | — | — | 1 | 6.37 |
| CHEMBL4862272 | — | — | 1 | 6.34 |
| CHEMBL4870469 | — | — | 1 | 6.28 |
| CHEMBL4865588 | — | — | 1 | 6.16 |
| CHEMBL4873869 | — | — | 1 | 6.06 |
| CHEMBL4869087 | — | — | 1 | 6.04 |
| CHEMBL4872706 | — | — | 1 | 6.00 |
| CHEMBL4861409 | — | — | 1 | 5.84 |
| CHEMBL4871841 | — | — | 1 | 5.65 |
| CHEMBL4853995 | — | — | 1 | 5.51 |
| CHEMBL4873489 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853530 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4846075 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4851068 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4853001 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4879051 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4862272 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4870469 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4865588 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4873869 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4869087 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4872706 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4861409 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4871841 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4853995 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4873489 | — | IC50 | = | 59000.0 | nM | 4.23 |