Assay Detail
Functional
CHEMBL4835696
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Antiplasmodial activity against asexual stage (IV/V) Plasmodium falciparum NF54 late gametocytes transfected with GFP-Luc assessed as inhibition of exflagellation of male gametes incubated for 48 hrs by microscopy based luciferase reporter gene assay relative to control
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and <i>In Vivo</i> Oral Efficacy Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.07 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.85 |
| CHEMBL4853530 | — | — | 1 | 5.72 |
| CHEMBL4853001 | — | — | 1 | 5.63 |
| CHEMBL4879051 | — | — | 1 | - |
| CHEMBL4846075 | — | — | 1 | - |
| CHEMBL4862272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4853530 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4853001 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4879051 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4846075 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4862272 | — | IC50 | > | 5000.0 | nM | - |