Assay Detail
Functional
CHEMBL4835798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.47 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.44 |
| CHEMBL438402 | — | — | 1 | 9.25 |
| CHEMBL264190 | — | — | 1 | 7.51 |
| CHEMBL4868636 | — | — | 1 | 6.68 |
| CHEMBL4848322 | — | — | 1 | 6.66 |
| CHEMBL4863206 | — | — | 1 | 6.62 |
| CHEMBL342954 | — | — | 1 | 6.58 |
| CHEMBL4864094 | — | — | 1 | 6.51 |
| CHEMBL4862172 | — | — | 1 | 6.46 |
| CHEMBL4868223 | — | — | 1 | 6.44 |
| CHEMBL4878201 | — | — | 1 | 6.44 |
| CHEMBL4846261 | — | — | 1 | 6.43 |
| CHEMBL4872932 | — | — | 1 | 6.38 |
| CHEMBL4877442 | — | — | 1 | 5.70 |
| CHEMBL4878558 | — | — | 1 | 5.55 |
| CHEMBL4856877 | — | — | 1 | 5.43 |
| CHEMBL4869531 | — | — | 1 | 5.40 |
| CHEMBL4877232 | — | — | 1 | 5.37 |
| CHEMBL4866532 | — | — | 1 | 5.28 |
| CHEMBL4869669 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL438402 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL264190 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4868636 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4848322 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4863206 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL342954 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4864094 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4862172 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4868223 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4878201 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4846261 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4872932 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4877442 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4878558 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4856877 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4869531 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4877232 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4866532 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4869669 | — | EC50 | = | 6200.0 | nM | 5.21 |