Assay Detail
Functional
CHEMBL4835801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.81 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342954 | — | — | 1 | 9.05 |
| CHEMBL438402 | — | — | 1 | 8.80 |
| CHEMBL264190 | — | — | 1 | 8.26 |
| CHEMBL4868636 | — | — | 1 | 6.57 |
| CHEMBL4868223 | — | — | 1 | 6.24 |
| CHEMBL4863206 | — | — | 1 | 6.19 |
| CHEMBL4871577 | — | — | 1 | 5.88 |
| CHEMBL4877537 | — | — | 1 | 5.17 |
| CHEMBL4878922 | — | — | 1 | 5.09 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342954 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL438402 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL264190 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4868636 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4868223 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4863206 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4871577 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4877537 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4878922 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.12 | nM | - |