Assay Detail
Functional
CHEMBL4835866
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Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion measured at day 7 post infection by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272427 | TAURURSODIOL | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272427 | TAURURSODIOL | IC50 | = | 3000.0 | nM | 5.52 |