Assay Detail
Functional
CHEMBL4836065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P2 receptor expressed in CHO cells assessed as calcium flux measured for 3 mins by fluorescence assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.38 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877932 | — | — | 1 | 5.55 |
| CHEMBL4874151 | — | — | 1 | 5.55 |
| CHEMBL4850513 | — | — | 1 | 5.52 |
| CHEMBL4846795 | — | — | 1 | 5.52 |
| CHEMBL4864274 | — | — | 1 | 5.50 |
| CHEMBL4847056 | — | — | 1 | 5.46 |
| CHEMBL4859853 | — | — | 1 | 5.46 |
| CHEMBL4860408 | — | — | 1 | 5.40 |
| CHEMBL4868016 | — | — | 1 | 5.38 |
| CHEMBL4858509 | — | — | 1 | 5.38 |
| CHEMBL4845783 | — | — | 1 | 5.36 |
| CHEMBL4878889 | — | — | 1 | 5.36 |
| CHEMBL4866666 | — | — | 1 | 5.36 |
| CHEMBL4874736 | — | — | 1 | 5.33 |
| CHEMBL4869752 | — | — | 1 | 5.32 |
| CHEMBL4858923 | — | — | 1 | 5.32 |
| CHEMBL4867946 | — | — | 1 | 5.31 |
| CHEMBL4847407 | — | — | 1 | 5.31 |
| CHEMBL4871481 | — | — | 1 | 5.30 |
| CHEMBL4861377 | — | — | 1 | 5.29 |
| CHEMBL4853790 | — | — | 1 | 5.28 |
| CHEMBL4860157 | — | — | 1 | 5.26 |
| CHEMBL4877484 | — | — | 1 | 5.26 |
| CHEMBL4856214 | — | — | 1 | - |
| CHEMBL4871414 | — | — | 1 | - |
| CHEMBL4862597 | — | — | 1 | - |
| CHEMBL4876986 | — | — | 1 | - |
| CHEMBL4847413 | — | — | 1 | - |
| CHEMBL4866695 | — | — | 1 | - |
| CHEMBL4873977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877932 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4874151 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4846795 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4850513 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4864274 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4847056 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4859853 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4860408 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4868016 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4858509 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4878889 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4866666 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4845783 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4874736 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4858923 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4869752 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4867946 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4847407 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4871481 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4861377 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4853790 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4877484 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4860157 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4845863 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4866312 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4870007 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4860509 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4867313 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4864744 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4852127 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4877928 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4873481 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4852473 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4873977 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4866695 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4847413 | — | IC50 | < | 1700.0 | nM | - |
| CHEMBL4876986 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4862597 | — | IC50 | < | 2300.0 | nM | - |
| CHEMBL4871414 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL4856214 | — | IC50 | < | 3000.0 | nM | - |