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Assay Detail

CHEMBL4836470

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Binding
Inhibition of aromatase (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Diterpenoids with Aromatase Inhibitory Activity from the Rhizomes of <i>Kaempferia elegans</i>.
Chawengrum P, Boonsombat J, Mahidol C, Eurtivong C, Kittakoop P, Thongnest S, Ruchirawat S.
J Nat Prod (2021) 84 : 1738 -1747
PubMed 34110821 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.87 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1444 LETROZOLE 4.0 1 9.00
CHEMBL1200374 EXEMESTANE 4.0 1 7.64
CHEMBL157101 KETOCONAZOLE 4.0 1 5.62
CHEMBL4852023 1 5.43
CHEMBL4875917 1 5.14
CHEMBL4874928 1 5.10
CHEMBL4863718 1 4.98
CHEMBL4859743 1 4.97
CHEMBL4866633 1 4.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1444 LETROZOLE IC50 = 1.0 nM 9.00
CHEMBL1200374 EXEMESTANE IC50 = 23.0 nM 7.64
CHEMBL157101 KETOCONAZOLE IC50 = 2400.0 nM 5.62
CHEMBL4852023 IC50 = 3700.0 nM 5.43
CHEMBL4875917 IC50 = 7200.0 nM 5.14
CHEMBL4874928 IC50 = 7900.0 nM 5.10
CHEMBL4863718 IC50 = 10400.0 nM 4.98
CHEMBL4859743 IC50 = 10700.0 nM 4.97
CHEMBL4866633 IC50 = 11800.0 nM 4.93