Assay Detail
Binding
CHEMBL4836515
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Inhibition of HDAC6 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Intracellular fluorescence competition assay for inhibitor engagement of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.59 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475116 | — | — | 1 | 8.32 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.30 |
| CHEMBL4864538 | — | — | 1 | 7.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.48 |
| CHEMBL4866882 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475116 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4864538 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4866882 | — | IC50 | = | 1120.0 | nM | 5.95 |