Assay Detail
Binding
CHEMBL4836604
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Inhibition of MTase activity of N-terminal 6XHis-tagged SARS-CoV-1 NSP14 (5903 to 6429 residues) expressed in Escherichia coli C41(DE3) using GpppAC5 and [3H]AdoMet as substrate incubated for 4 hrs by filter binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 496.0 | nM | 6.30 |