Assay Detail
Functional
CHEMBL4836637
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Inhibition of LPS-induced MCP1 production in human PBMC cells incubated for 30 mins followed by LPS stimulation and measured after 24 hrs by mesoscale assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.83 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848969 | — | — | 1 | 8.10 |
| CHEMBL4851125 | — | — | 1 | 7.70 |
| CHEMBL4869149 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848969 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4851125 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4869149 | — | IC50 | = | 19.95 | nM | 7.70 |