Assay Detail
Binding
CHEMBL4836860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length His-tagged p110gamma expressed in baculovirus expression system measured after 60 mins in presence of ATP by ATP-competitive binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.49 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871071 | — | — | 1 | 8.12 |
| CHEMBL4868117 | — | — | 1 | 8.07 |
| CHEMBL4862467 | — | — | 1 | 7.98 |
| CHEMBL4845946 | — | — | 1 | 7.82 |
| CHEMBL4876309 | — | — | 1 | 7.74 |
| CHEMBL4852166 | — | — | 1 | 7.72 |
| CHEMBL4852863 | — | — | 1 | 7.61 |
| CHEMBL4858100 | — | — | 1 | 7.61 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.56 |
| CHEMBL4874404 | — | — | 1 | 7.54 |
| CHEMBL4854194 | — | — | 1 | 7.25 |
| CHEMBL4853740 | — | — | 1 | 7.20 |
| CHEMBL4876188 | — | — | 1 | 7.20 |
| CHEMBL4874496 | — | — | 1 | 7.14 |
| CHEMBL4870032 | — | — | 1 | 6.81 |
| CHEMBL4847494 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871071 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4868117 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4862467 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4845946 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4876309 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL4852166 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL4852863 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL4858100 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL4874404 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4854194 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL4853740 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL4876188 | — | IC50 | = | 63.8 | nM | 7.20 |
| CHEMBL4874496 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL4870032 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4847494 | — | IC50 | = | 313.0 | nM | 6.50 |