Assay Detail
Binding
CHEMBL4836940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-labeled Bak BH3 peptide binding to GST-tagged MCL1 (171 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins fluorescence polarization-based competitive binding assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 3,5-Dimethyl-4-Sulfonyl-1<i>H</i>-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 6.58 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 8.22 |
| CHEMBL4845828 | — | — | 1 | 7.75 |
| CHEMBL4850731 | — | — | 1 | 7.70 |
| CHEMBL4848900 | — | — | 1 | 7.40 |
| CHEMBL4865403 | — | — | 1 | 7.22 |
| CHEMBL4872248 | — | — | 1 | 7.16 |
| CHEMBL4848433 | — | — | 1 | 7.16 |
| CHEMBL4866213 | — | — | 1 | 7.10 |
| CHEMBL4849603 | — | — | 1 | 6.92 |
| CHEMBL4862358 | — | — | 1 | 6.89 |
| CHEMBL4868509 | — | — | 1 | 6.85 |
| CHEMBL4851153 | — | — | 1 | 6.82 |
| CHEMBL4860413 | — | — | 1 | 6.82 |
| CHEMBL4872240 | — | — | 1 | 6.77 |
| CHEMBL4868575 | — | — | 1 | 6.77 |
| CHEMBL4849319 | — | — | 1 | 6.75 |
| CHEMBL4856732 | — | — | 1 | 6.72 |
| CHEMBL4873329 | — | — | 1 | 6.70 |
| CHEMBL4873637 | — | — | 1 | 6.70 |
| CHEMBL4853919 | — | — | 1 | 6.62 |
| CHEMBL4878600 | — | — | 1 | 6.58 |
| CHEMBL4848776 | — | — | 1 | 6.47 |
| CHEMBL4872295 | — | — | 1 | 6.47 |
| CHEMBL4846014 | — | — | 1 | 6.44 |
| CHEMBL4849994 | — | — | 1 | 6.42 |
| CHEMBL4852847 | — | — | 1 | 6.38 |
| CHEMBL4857430 | — | — | 1 | 6.38 |
| CHEMBL4851400 | — | — | 1 | 6.37 |
| CHEMBL4871992 | — | — | 1 | 6.33 |
| CHEMBL4846741 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4845828 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4850731 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4848900 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL4865403 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL4872248 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4848433 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4866213 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL4849603 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4862358 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL4868509 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4851153 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4860413 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4872240 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4868575 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4849319 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL4856732 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4873329 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4873637 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4853919 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4878600 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL4848776 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL4872295 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL4846014 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4849994 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL4857430 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4852847 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4851400 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL4871992 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4846741 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4849257 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL4865519 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL4846109 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL4859893 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL4858756 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4873135 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4866578 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4859505 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL4876157 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4875261 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL4851426 | — | Ki | = | 5340.0 | nM | 5.27 |
| CHEMBL4871548 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4862130 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4854760 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4297482 | AZD-5991 | Ki | < | 1.0 | nM | - |
| CHEMBL4857932 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4868781 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4858493 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4862359 | — | Ki | > | 10000.0 | nM | - |