Assay Detail
Functional
CHEMBL4836952
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Antiproliferative activity against human SK-BR-3 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,5-Dimethyl-4-Sulfonyl-1<i>H</i>-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.22 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850731 | — | — | 1 | 5.55 |
| CHEMBL4848433 | — | — | 1 | 5.41 |
| CHEMBL3417704 | — | — | 1 | 5.37 |
| CHEMBL4866213 | — | — | 1 | 5.29 |
| CHEMBL4848900 | — | — | 1 | 5.25 |
| CHEMBL4872248 | — | — | 1 | 5.20 |
| CHEMBL4845828 | — | — | 1 | 5.15 |
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850731 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4848433 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL3417704 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4866213 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL4848900 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4872248 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4845828 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL4297482 | AZD-5991 | IC50 | = | 30000.0 | nM | 4.52 |