Assay Detail
Functional
CHEMBL4836954
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Antiproliferative activity against human K562 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,5-Dimethyl-4-Sulfonyl-1<i>H</i>-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.77 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866213 | — | — | 1 | 4.95 |
| CHEMBL4845828 | — | — | 1 | 4.83 |
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 4.53 |
| CHEMBL3417704 | — | — | 1 | - |
| CHEMBL4850731 | — | — | 1 | - |
| CHEMBL4872248 | — | — | 1 | - |
| CHEMBL4848900 | — | — | 1 | - |
| CHEMBL4848433 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866213 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4845828 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4297482 | AZD-5991 | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL3417704 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4850731 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4872248 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4848900 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4848433 | — | IC50 | > | 30000.0 | nM | - |