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Assay Detail

CHEMBL4837809

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Functional
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition by DPPH assay relative to control
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Ayoup MS, Abu-Serie MM, Abdel-Hamid H, Teleb M.
Eur J Med Chem (2021) 220 : 113475 -113475
PubMed 33901898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.83 6.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4859206 1 6.37
CHEMBL196 ASCORBIC ACID 4.0 1 6.34
CHEMBL4849098 1 6.23
CHEMBL1876217 1 6.04
CHEMBL4878860 1 5.93
CHEMBL4849370 1 5.89
CHEMBL4758512 1 5.87
CHEMBL4877251 1 5.77
CHEMBL4876222 1 5.72
CHEMBL560774 1 5.71
CHEMBL4866288 1 5.71
CHEMBL4850560 1 5.66
CHEMBL2069933 1 5.52
CHEMBL4850245 1 5.46
CHEMBL4860232 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4859206 IC50 = 423.0 nM 6.37
CHEMBL196 ASCORBIC ACID IC50 = 461.0 nM 6.34
CHEMBL4849098 IC50 = 585.0 nM 6.23
CHEMBL1876217 IC50 = 912.0 nM 6.04
CHEMBL4878860 IC50 = 1164.0 nM 5.93
CHEMBL4849370 IC50 = 1288.0 nM 5.89
CHEMBL4758512 IC50 = 1343.0 nM 5.87
CHEMBL4877251 IC50 = 1693.0 nM 5.77
CHEMBL4876222 IC50 = 1896.0 nM 5.72
CHEMBL560774 IC50 = 1973.0 nM 5.71
CHEMBL4866288 IC50 = 1966.0 nM 5.71
CHEMBL4850560 IC50 = 2176.0 nM 5.66
CHEMBL2069933 IC50 = 3041.0 nM 5.52
CHEMBL4850245 IC50 = 3442.0 nM 5.46
CHEMBL4860232 IC50 = 5625.0 nM 5.25