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Assay Detail

CHEMBL4837810

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Metal chelating activity of the compound assessed as decrease in the Fe2+-phenanthroline complex formation incubated for 10 mins by microplate reader
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Ayoup MS, Abu-Serie MM, Abdel-Hamid H, Teleb M.
Eur J Med Chem (2021) 220 : 113475 -113475
PubMed 33901898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.84 7.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4849098 1 7.35
CHEMBL1749 EDETATE DISODIUM ANHYDROUS 4.0 1 7.26
CHEMBL4859206 1 7.20
CHEMBL1876217 1 6.99
CHEMBL4849370 1 6.96
CHEMBL4878860 1 6.93
CHEMBL4758512 1 6.91
CHEMBL4877251 1 6.81
CHEMBL4876222 1 6.75
CHEMBL560774 1 6.73
CHEMBL4866288 1 6.67
CHEMBL4850560 1 6.66
CHEMBL4850245 1 6.53
CHEMBL2069933 1 6.48
CHEMBL4860232 1 6.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4849098 EC50 = 45.0 nM 7.35
CHEMBL1749 EDETATE DISODIUM ANHYDROUS EC50 = 55.0 nM 7.26
CHEMBL4859206 EC50 = 63.0 nM 7.20
CHEMBL1876217 EC50 = 103.0 nM 6.99
CHEMBL4849370 EC50 = 110.0 nM 6.96
CHEMBL4878860 EC50 = 118.0 nM 6.93
CHEMBL4758512 EC50 = 124.0 nM 6.91
CHEMBL4877251 EC50 = 154.0 nM 6.81
CHEMBL4876222 EC50 = 177.0 nM 6.75
CHEMBL560774 EC50 = 185.0 nM 6.73
CHEMBL4866288 EC50 = 213.0 nM 6.67
CHEMBL4850560 EC50 = 219.0 nM 6.66
CHEMBL4850245 EC50 = 297.0 nM 6.53
CHEMBL2069933 EC50 = 328.0 nM 6.48
CHEMBL4860232 EC50 = 406.0 nM 6.39