Assay Detail
Functional
CHEMBL4837812
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Anticancer activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.37 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859206 | — | — | 1 | 7.83 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL1876217 | — | — | 1 | 7.63 |
| CHEMBL4849098 | — | — | 1 | 7.56 |
| CHEMBL4877251 | — | — | 1 | 7.45 |
| CHEMBL4850245 | — | — | 1 | 7.41 |
| CHEMBL4878860 | — | — | 1 | 7.38 |
| CHEMBL4876222 | — | — | 1 | 7.33 |
| CHEMBL4849370 | — | — | 1 | 7.30 |
| CHEMBL4850560 | — | — | 1 | 7.29 |
| CHEMBL2069933 | — | — | 1 | 7.27 |
| CHEMBL560774 | — | — | 1 | 7.26 |
| CHEMBL4866288 | — | — | 1 | 7.09 |
| CHEMBL4758512 | — | — | 1 | 7.06 |
| CHEMBL4860232 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859206 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1876217 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4849098 | — | IC50 | = | 27.3 | nM | 7.56 |
| CHEMBL4877251 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL4850245 | — | IC50 | = | 38.8 | nM | 7.41 |
| CHEMBL4878860 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL4876222 | — | IC50 | = | 46.6 | nM | 7.33 |
| CHEMBL4849370 | — | IC50 | = | 49.8 | nM | 7.30 |
| CHEMBL4850560 | — | IC50 | = | 50.7 | nM | 7.29 |
| CHEMBL2069933 | — | IC50 | = | 53.9 | nM | 7.27 |
| CHEMBL560774 | — | IC50 | = | 55.4 | nM | 7.26 |
| CHEMBL4866288 | — | IC50 | = | 80.4 | nM | 7.09 |
| CHEMBL4758512 | — | IC50 | = | 87.7 | nM | 7.06 |
| CHEMBL4860232 | — | IC50 | = | 97.7 | nM | 7.01 |