Assay Detail
Functional
CHEMBL4837813
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Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.54 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877251 | — | — | 1 | 7.95 |
| CHEMBL4878860 | — | — | 1 | 7.93 |
| CHEMBL2069933 | — | — | 1 | 7.87 |
| CHEMBL4850245 | — | — | 1 | 7.86 |
| CHEMBL4849370 | — | — | 1 | 7.77 |
| CHEMBL4876222 | — | — | 1 | 7.73 |
| CHEMBL4758512 | — | — | 1 | 7.63 |
| CHEMBL4866288 | — | — | 1 | 7.30 |
| CHEMBL4859206 | — | — | 1 | 7.21 |
| CHEMBL1876217 | — | — | 1 | 7.19 |
| CHEMBL4849098 | — | — | 1 | 7.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877251 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4878860 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL2069933 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4850245 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4849370 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4876222 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL4758512 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4866288 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL4859206 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL1876217 | — | IC50 | = | 64.3 | nM | 7.19 |
| CHEMBL4849098 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 106.0 | nM | 6.97 |