Assay Detail
Functional
CHEMBL4837814
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Anticancer activity against human Caco-2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560774 | — | — | 1 | 7.92 |
| CHEMBL4859206 | — | — | 1 | 7.86 |
| CHEMBL1876217 | — | — | 1 | 7.60 |
| CHEMBL4849098 | — | — | 1 | 7.57 |
| CHEMBL4878860 | — | — | 1 | 7.46 |
| CHEMBL4758512 | — | — | 1 | 7.43 |
| CHEMBL4850560 | — | — | 1 | 7.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.32 |
| CHEMBL2069933 | — | — | 1 | 7.29 |
| CHEMBL4866288 | — | — | 1 | 7.11 |
| CHEMBL4877251 | — | — | 1 | 6.62 |
| CHEMBL4860232 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560774 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL4859206 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL1876217 | — | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL4849098 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL4878860 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL4758512 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL4850560 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 48.1 | nM | 7.32 |
| CHEMBL2069933 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL4866288 | — | IC50 | = | 77.5 | nM | 7.11 |
| CHEMBL4877251 | — | IC50 | = | 242.6 | nM | 6.62 |
| CHEMBL4860232 | — | IC50 | = | 317.6 | nM | 6.50 |