Assay Detail
Binding
CHEMBL4837833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assay
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thioredoxin reductase 1, cytoplasmic (CHEMBL1927) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.82 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859206 | — | — | 2 | 8.04 |
| CHEMBL1876217 | — | — | 2 | 7.88 |
| CHEMBL4849098 | — | — | 2 | 7.75 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859206 | — | IC50 | = | 9.21 | nM | 8.04 |
| CHEMBL4859206 | — | IC50 | = | 9.226 | nM | 8.04 |
| CHEMBL1876217 | — | IC50 | = | 13.19 | nM | 7.88 |
| CHEMBL1876217 | — | IC50 | = | 13.21 | nM | 7.88 |
| CHEMBL4849098 | — | IC50 | = | 17.89 | nM | 7.75 |
| CHEMBL4849098 | — | IC50 | = | 17.91 | nM | 7.75 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 43.18 | nM | 7.37 |