Assay Detail
Binding
CHEMBL4837837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay technique
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.71 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859206 | — | — | 2 | 7.97 |
| CHEMBL1876217 | — | — | 2 | 7.79 |
| CHEMBL4849098 | — | — | 2 | 7.66 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859206 | — | IC50 | = | 10.71 | nM | 7.97 |
| CHEMBL4859206 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL1876217 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL1876217 | — | IC50 | = | 16.41 | nM | 7.79 |
| CHEMBL4849098 | — | IC50 | = | 21.94 | nM | 7.66 |
| CHEMBL4849098 | — | IC50 | = | 21.98 | nM | 7.66 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 70.77 | nM | 7.15 |