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Assay Detail

CHEMBL4838119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells.
İbiş K, Nalbat E, Çalışkan B, Kahraman DC, Cetin-Atalay R, Banoglu E.
Eur J Med Chem (2021) 221 : 113489 -113489
PubMed 33951549 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 5.75 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4862133 1 7.00
CHEMBL4850692 1 7.00
CHEMBL4855454 1 6.52
CHEMBL4867559 1 6.42
CHEMBL4862691 1 6.40
CHEMBL4873417 1 6.16
CHEMBL4870788 1 6.10
CHEMBL4872585 1 5.92
CHEMBL4849381 1 5.92
CHEMBL4871080 1 5.89
CHEMBL4875579 1 5.85
CHEMBL4874013 1 5.85
CHEMBL4855049 1 5.85
CHEMBL4862639 1 5.82
CHEMBL4862382 1 5.80
CHEMBL4870937 1 5.75
CHEMBL4847541 1 5.75
CHEMBL4874845 1 5.72
CHEMBL4845985 1 5.70
CHEMBL4860276 1 5.70
CHEMBL4855836 1 5.62
CHEMBL4845898 1 5.62
CHEMBL4873537 1 5.60
CHEMBL4853227 1 5.60
CHEMBL4854136 1 5.57
CHEMBL4857888 1 5.55
CHEMBL4878697 1 5.55
CHEMBL4861159 1 5.54
CHEMBL4874037 1 5.52
CHEMBL4854409 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4862133 IC50 = 100.0 nM 7.00
CHEMBL4850692 IC50 = 100.0 nM 7.00
CHEMBL4855454 IC50 = 300.0 nM 6.52
CHEMBL4867559 IC50 = 380.0 nM 6.42
CHEMBL4862691 IC50 = 400.0 nM 6.40
CHEMBL4873417 IC50 = 700.0 nM 6.16
CHEMBL4870788 IC50 = 800.0 nM 6.10
CHEMBL4872585 IC50 = 1200.0 nM 5.92
CHEMBL4849381 IC50 = 1200.0 nM 5.92
CHEMBL4871080 IC50 = 1300.0 nM 5.89
CHEMBL4875579 IC50 = 1400.0 nM 5.85
CHEMBL4855049 IC50 = 1400.0 nM 5.85
CHEMBL4874013 IC50 = 1400.0 nM 5.85
CHEMBL4862639 IC50 = 1500.0 nM 5.82
CHEMBL4862382 IC50 = 1600.0 nM 5.80
CHEMBL4870937 IC50 = 1800.0 nM 5.75
CHEMBL4847541 IC50 = 1800.0 nM 5.75
CHEMBL4874845 IC50 = 1900.0 nM 5.72
CHEMBL4860276 IC50 = 2000.0 nM 5.70
CHEMBL4845985 IC50 = 2000.0 nM 5.70
CHEMBL4855836 IC50 = 2400.0 nM 5.62
CHEMBL4845898 IC50 = 2400.0 nM 5.62
CHEMBL4873537 IC50 = 2500.0 nM 5.60
CHEMBL4853227 IC50 = 2500.0 nM 5.60
CHEMBL4854136 IC50 = 2700.0 nM 5.57
CHEMBL4857888 IC50 = 2800.0 nM 5.55
CHEMBL4878697 IC50 = 2800.0 nM 5.55
CHEMBL4861159 IC50 = 2900.0 nM 5.54
CHEMBL4874037 IC50 = 3000.0 nM 5.52
CHEMBL4854409 IC50 = 3500.0 nM 5.46
CHEMBL4860205 IC50 = 3700.0 nM 5.43
CHEMBL4867753 IC50 = 3800.0 nM 5.42
CHEMBL4846438 IC50 = 3800.0 nM 5.42
CHEMBL4878256 IC50 = 4000.0 nM 5.40
CHEMBL4846358 IC50 = 4000.0 nM 5.40
CHEMBL4871266 IC50 = 6700.0 nM 5.17
CHEMBL4861490 IC50 = 7600.0 nM 5.12
CHEMBL4851540 IC50 = 7900.0 nM 5.10
CHEMBL4855132 IC50 = 8400.0 nM 5.08