Assay Detail
Functional
CHEMBL4838217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as rescue of virus reduced eGFP signals by SARS-CoV-2 antiviral assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.71 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.05 |
| CHEMBL4848917 | — | — | 1 | 4.51 |
| CHEMBL4876314 | — | — | 1 | 4.46 |
| CHEMBL4854432 | — | — | 1 | 4.36 |
| CHEMBL3577819 | — | — | 1 | 4.18 |
| CHEMBL3577818 | — | — | 1 | - |
| CHEMBL4856458 | — | — | 1 | - |
| CHEMBL4865370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4848917 | — | EC50 | = | 30610.0 | nM | 4.51 |
| CHEMBL4876314 | — | EC50 | = | 34470.0 | nM | 4.46 |
| CHEMBL4854432 | — | EC50 | = | 43960.0 | nM | 4.36 |
| CHEMBL3577819 | — | EC50 | = | 65350.0 | nM | 4.18 |
| CHEMBL3577818 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4856458 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4865370 | — | EC50 | > | 100000.0 | nM | - |