Assay Detail
Binding
CHEMBL4838276
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Inhibition of p37 in Cowpox virus Grishak infected in African green monkey Vero cells assessed as reduction in viral reproduction incubated for 4 days by neutral red dye based colorimetric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cowpox virus |
| Cell Type | Vero |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.50 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257073 | TECOVIRIMAT | 4.0 | 1 | 8.27 |
| CHEMBL4864184 | — | — | 1 | 6.03 |
| CHEMBL4867155 | — | — | 1 | 6.02 |
| CHEMBL4871145 | — | — | 1 | 5.91 |
| CHEMBL4857491 | — | — | 1 | 5.39 |
| CHEMBL4850454 | — | — | 1 | 5.32 |
| CHEMBL4852852 | — | — | 1 | 4.99 |
| CHEMBL4879134 | — | — | 1 | 4.96 |
| CHEMBL4865942 | — | — | 1 | 4.95 |
| CHEMBL4853135 | — | — | 1 | 4.92 |
| CHEMBL4856490 | — | — | 1 | 4.81 |
| CHEMBL4877767 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257073 | TECOVIRIMAT | IC50 | = | 5.32 | nM | 8.27 |
| CHEMBL4864184 | — | IC50 | = | 928.0 | nM | 6.03 |
| CHEMBL4867155 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4871145 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4857491 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4850454 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4852852 | — | IC50 | = | 10360.0 | nM | 4.99 |
| CHEMBL4879134 | — | IC50 | = | 11060.0 | nM | 4.96 |
| CHEMBL4865942 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4853135 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4856490 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4877767 | — | IC50 | = | 32900.0 | nM | 4.48 |