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Assay Detail

CHEMBL4838787

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 96 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Puxeddu M, Shen H, Bai R, Coluccia A, Bufano M, Nalli M, Sebastiani J, Brancaccio D, Da Pozzo E, Tremolanti C, Martini C, Orlando V, Biagioni S, Sinicropi MS, Ceramella J, Iacopetta D, Coluccia AML, Hamel E, Liu T, Silvestri R, La Regina G.
Eur J Med Chem (2021) 221 : 113532 -113532
PubMed 34052717 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.58 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4864675 1 8.40
CHEMBL4854987 1 8.05
CHEMBL4848963 1 8.05
CHEMBL4559506 1 7.85
CHEMBL4854386 1 7.85
CHEMBL4854277 1 7.82
CHEMBL4875751 1 7.82
CHEMBL4857244 1 7.77
CHEMBL4847641 1 7.75
CHEMBL4858659 1 7.72
CHEMBL4857653 1 7.70
CHEMBL4873209 1 7.68
CHEMBL4878868 1 7.66
CHEMBL4847168 1 7.66
CHEMBL4862699 1 7.64
CHEMBL4845944 1 7.44
CHEMBL4867095 1 7.41
CHEMBL4863951 1 7.38
CHEMBL4870805 1 7.28
CHEMBL4856000 1 7.19
CHEMBL4866397 1 7.19
CHEMBL4850863 1 7.14
CHEMBL4868699 1 7.12
CHEMBL4872489 1 7.03
CHEMBL4868298 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4864675 IC50 = 4.0 nM 8.40
CHEMBL4854987 IC50 = 9.0 nM 8.05
CHEMBL4848963 IC50 = 9.0 nM 8.05
CHEMBL4559506 IC50 = 14.0 nM 7.85
CHEMBL4854386 IC50 = 14.0 nM 7.85
CHEMBL4854277 IC50 = 15.0 nM 7.82
CHEMBL4875751 IC50 = 15.0 nM 7.82
CHEMBL4857244 IC50 = 17.0 nM 7.77
CHEMBL4847641 IC50 = 18.0 nM 7.75
CHEMBL4858659 IC50 = 19.0 nM 7.72
CHEMBL4857653 IC50 = 20.0 nM 7.70
CHEMBL4873209 IC50 = 21.0 nM 7.68
CHEMBL4878868 IC50 = 22.0 nM 7.66
CHEMBL4847168 IC50 = 22.0 nM 7.66
CHEMBL4862699 IC50 = 23.0 nM 7.64
CHEMBL4845944 IC50 = 36.0 nM 7.44
CHEMBL4867095 IC50 = 39.0 nM 7.41
CHEMBL4863951 IC50 = 42.0 nM 7.38
CHEMBL4870805 IC50 = 52.0 nM 7.28
CHEMBL4856000 IC50 = 65.0 nM 7.19
CHEMBL4866397 IC50 = 65.0 nM 7.19
CHEMBL4850863 IC50 = 73.0 nM 7.14
CHEMBL4868699 IC50 = 75.0 nM 7.12
CHEMBL4872489 IC50 = 93.0 nM 7.03
CHEMBL4868298 IC50 = 140.0 nM 6.85