Assay Detail
Functional
CHEMBL4838803
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Cytotoxicity against imatinib mesylate resistant wild-type human KBM5 cells expressing T315I mutant assessed as cell growth inhibition measured after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBM5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864675 | — | — | 1 | 8.06 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.97 |
| CHEMBL4854987 | — | — | 1 | 7.88 |
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864675 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4854987 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 310.6 | nM | 6.51 |